Biomarkers
SYRINX offers a wide range of biomarker assays to support your drug development program. We can either offer you an already established bioanalytical method or we can set up an assay for your specific needs (matrix, species, etc.). All assays can be validated according to GLP (please enquire for validation status).
Please send your enquiries here.
Biomarkers currently available at SYRINX Bioanalytics:
| 4EBP1 (pT37/46) | GSK-3b (total) (rat) | Myl3 (rat) |
| 4EBP1 (total) | GSTYb1 (rat) | Myoglobin |
| 4EBP1 (total) (mouse) | hAFP | NFkB (pS468) |
| A2M (rat) | hAFP/Free hCGß | NFkB (pS536) |
| Abeta 38 | hCG | NFkB (total) |
| Abeta 38 (mouse) | hFSH | NGAL |
| Abeta 38 (rat) | HGF | NSO-P |
| Abeta 40 | HGFR/c-MET | NT-proBNP |
| Abeta 40 (mouse) | HIF-1a | Osteocalcin |
| Abeta 40 (rat) | HIF-1a (mouse) | Osteonectin |
| Abeta 42 | HIF-1a (rat) | Osteopontin |
| Abeta 42 (mouse) | Histone H3 (pS10) | Osteoprotegerin |
| Abeta 42 (rat) | Histone H3 (pS10) (mouse) | p21 (total) |
| Active Ghrelin | Histone H3 (pS10) (rat) | p38 (pT180/pY182) |
| Active GLP-1 (7-36) amide | HIV p24 | p38 (pT180/pY182) (mouse) |
| Active GLP-1 (7-36) amide (rat) | HIV p24 (high sensitivity) | p38 (pT180/pY182) (rat) |
| Active GLP-1 (7-36) amide (mouse) | HSP27 (pS15) | p38 (total) |
| Active GLP-1 (canine) | HSP27 (pS78) | p38 (total) (mouse) |
| Active GLP-1 (ver. 2) | HSP27 (pS82) | p38 (total) (rat) |
| Active GLP-1 (ver. 2) (mouse) | HSP27 (total) | p53 (pS15) |
| Active GLP-1 (ver. 2) (rat) | HSP70 (total) | p53 (total) |
| Adiponectin | hTG | p53 (total) (mouse) |
| Adiponectin (mouse) | hTgAb | p53 (total) (rat) |
| Adiponectin (mouse) | hTSH | p53 (ubiquitinated) |
| Adiponectin (rat) | ICAM-1 | p53 (ubiquitinated) (mouse) |
| AFP | IFN-a2a | p53 (ubiquitinated) (rat) |
| AGP (rat) | IFN-α | p70S6K (pT389) |
| aGST (rat) | IFN-β | p70S6K (pT389) (mouse) |
| Akt (pS473) | IFN-γ | p70S6K (pT389) (rat) |
| Akt (pS473) (mouse) | IFN-γ (canine) | p70S6K (pT421/pS424) |
| Akt (pS473) (rat) | IFN-γ (mouse) | p70S6K (pT421/pS424) (mouse) |
| Akt (pT308) | IFN-γ (rat) | p70S6K (pT421/pS424) (rat) |
| Akt (pT308) (mouse) | IgA | p70S6K (total) |
| Akt (total) | IgE | p70S6K (total) (mouse) |
| Akt (total) (mouse) | IGF1 | p70S6K (total) (rat) |
| Akt (total) (rat) | IGF-1R (pY) | PAI-1 |
| Albumin | IGF-1R (total) | PAPP-A |
| Albumin (mouse) | IGF2 | PARP (D214) (cleaved) |
| Albumin (rat) | IGFBP-1 | P-Cadherin |
| ALP | IgG | PCSK9 |
| Alpha-2 macroglobulin | IgM | PDGFR-b (pY751) |
| AMPK-a1 (pS485) | IL-10 | PDGFR-b (pY751) (mouse) |
| AMPK-a1 (pT174/172) | IL-10 (canine) | PEDF/Serpin F1 |
| AMPK-a1 (total) | IL-10 (mouse) | PlGF |
| Amyloid ß 1-40 (mouse/rat) | IL-10 (mouse) | PRAS40 (pT246) |
| Amyloid β 1-15/16 | IL-10 (rat) | PRAS40 (pT246) (mouse) |
| Amyloid β 1-40 | IL-11 | PRAS40 (pT246) (rat) |
| Amyloid β 1-40 (high specificity) | IL-12 | PRAS40 (total) |
| Amyloid β 1-42 | IL-12 (mouse) | Progesterone |
| Amyloid β 1-42 (high specificity) | IL-12 (p70) | Progesterone |
| Amyloid β 1-42 (mouse/rat) | IL-12 p40 | Prolactin |
| Amyloid β 1-x | IL-12 p40 (mouse) | Prolactin |
| Amyloid β oligomers | IL-12 p70 | Prolactin |
| Angiopoietin 1 | IL-12 p70 (mouse) | PSA |
| Angiopoietin 2 | IL-13 | P-Selectin |
| Anti-tissue Transglutaminase IgA | IL-13 | RANTES |
| Apolipoprotein A1 | IL-13 (mouse) | RANTES (mouse) |
| Apolipoprotein C3 | IL-13 (rat) | Rb (pS608) |
| Aurora A (pT288) | IL-15 | Rb (pS780) |
| B12 | IL-15 | Rb (total) |
| BAD (pS112) | IL-15 (mouse) | Renin/Prorenin |
| BAD (total) | IL-16 | Residual Protein A |
| BDNF | IL-17 | Resistin |
| b-NGF | IL-17 | Resistin (mouse) |
| b-Secretase (activity assay) | IL-17 (mouse) | Resistin (rat) |
| CA125 | IL-17A (mouse/rat) | RON (pT1238/1239) |
| Calprotectin | IL-18 | RPA-1 (rat) |
| cAMP | IL-18 | S6RP (pS235/236) |
| cAMP (mouse) | IL-1a | S6RP (pS235/236) (mouse) |
| cAMP (rat) | IL-1a (rat) | S6RP (pS235/236) (rat) |
| Cancer Antigen 125 | IL-1b | S6RP (pS240/244) |
| Cancer Antigen 15.3 | IL-1b (mouse) | S6RP (pS240/244) (mouse) |
| Cancer Antigen 19.9 | IL-1b (rat) | S6RP (pS240/244) (rat) |
| Cardiac Troponin I | IL-1ra | S6RP (total) |
| Cardiac Troponin I (rat) | IL1α | S6RP (total) (mouse) |
| Cardiac Troponin T (rat) | IL1β | S6RP (total) (rat) |
| Caspase-3 (p20/p17) cleaved | IL1β (mouse) | SAA |
| Caspase-3 (total) | IL1β (rat) | sAPPa |
| Caspase-3 active | IL-2 | sAPPb |
| CCL2/MCP1 | IL-2 | sAPPb (mouse) |
| CCL2/MCP1 (mouse/rat) | IL-2 (canine) | sAPPb (rat) |
| CCL3/MIP-1α | IL-2 (mouse) | sAPPb sw |
| CCL4/MIP-1β | IL-2 (mouse) | sAPPα (C-term specific) |
| CCL5 / RANTES | IL-2 (rat) | sAPPβ |
| CCL5 / RANTES (mouse) | IL-23 | sAPPβ (high sensitivity) |
| CEA | IL-3 | Sclerostin |
| Celiac disease hybridization assay | IL-4 | SDF-1a |
| Central Nervous System | IL-4 | sEGFR |
| Chk1 (pS296) | IL-4 (mouse) | sErbB2 |
| CHO-P | IL-4 (rat) | sFas |
| CINC-2 (rat) | IL-5 | sFlt-1 (sVEGFR1) |
| CINC-3 (rat) | IL-5 | SHBG |
| c-Jun (pS63) | IL-5 (mouse) | sICAM-1 |
| c-Jun (pS63) (mouse) | IL-5 (rat) | sICAM-1 (rat) |
| c-Jun (pS63) (rat) | IL-6 | sICAM-3 |
| c-Kit (pY721) | IL-6 | Skeletal Troponin I (rat) |
| c-Kit (total) | IL-6 (canine) | sMet |
| CKMB | IL-6 (mouse) | sRAGE |
| Clusterin (rat) | IL-6 (mouse) | sRAGE (mouse) |
| CNTF-1 (rat) | IL-6 (rat) | sRAGE (rat) |
| COMP | IL-6R | STAT3 (pY705) |
| C-peptide | IL-7 | STAT3 (pY705) (mouse) |
| C-peptide (mouse/rat) | IL-7 | STAT3 (pY705) (rat) |
| C-Peptide (rat) | IL-7 (mouse) | STAT4 (pY693) |
| CRP | IL-8 | STAT4 (total) |
| CTACK | IL-8 | STAT5a/b (pY694) |
| CXCL1/GRO-α | IL-8 (canine) | STAT5a/b (pY694) (mouse) |
| CXCL10/IP-10 | Immunoglobulin isotyping (IgGA, IgG1, IgG2a, IgG2b, IgG3, IgM) | STAT5a/b (total) |
| CXCL11/I-TAC | Immunoglobulin isotyping (IgGA, IgG1, IgG2a, IgG2b, IgG3, IgM) (mouse) | STAT5a/b (total) (mouse) |
| CXCL9/MIG | Insulin | sVCAM-1 |
| Cystatin C | Insulin (mouse) | T3 |
| D-dimer | Insulin (rat) | T3 (mouse) |
| DHEA | IP-10 | T3 (rat) |
| E. coli HCP | IR (pY) | T4 |
| E-Cadherin | IR (total) | T4 (mouse) |
| EGF | IRS-1 (pS312) | T4 (rat) |
| EGF-R | IRS-1 (total) | TARC |
| EGFR (pY1068) | I-TAC | Tau |
| EGFR (pY1173) | JAK2 (pY1007/1008) | Tau (pS202) |
| EGFR (total) | JAK2 (total) | Tau (pS262) |
| eIF2a (pS51) | JNK (pT183/pY185) | Tau (pS396) |
| eIF2a (pS51) (mouse) | JNK (pT183/pY185) (mouse) | Tau (pT181) |
| eIF2a (pS51) (rat) | JNK (pT183/pY185) (rat) | Tau (pT231) |
| ENA-78 | JNK (total) | Tau (pT231) (mouse) |
| Endoglin | KC/GRO/CINC (CXCL1) (mouse) | Tau (total) |
| Eotaxin | KC/GRO/CINC (CXCL1) (rat) | Tau (total) (mouse) |
| Eotaxin-3 | KDR (sVEGFR2) | Testosterone |
| EphB4 (total) | LBP | TFF3 |
| EPO | Leptin | TGF-b1 |
| EPO (mouse) | Leptin (mouse) | TGF-b2 |
| EPO (rat) | Leptin (rat) | TGF-b3 |
| ErbB2 (pY1248) | Lipocalin-2 (rat) | Thrombomodulin |
| ErbB2 (total) | L-Selectin (rat) | TIM-1/KIM-1/HAVCR (rat) |
| ERBB2/HER2 | Luteinizing Hormone (LH) | TIMP1 |
| ErbB3 (HER3) (pY) | MAPKAPK-2 (pT334) | TIMP-1 |
| ERK-1/2 (pT202/pY204, pT185/pY187) | MAPKAPK-2 (pT334) (mouse) | TIMP-1 (rat) |
| ERK-1/2 (pT202/pY204, pT185/pY187) (mouse) | MCP-1 | TIMP-2 |
| ERK-1/2 (pT202/pY204, pT185/pY187) (rat) | MCP-1 (canine) | TNF-RI |
| ERK-1/2 (total) | MCP-1 (mouse) | TNF-RI (mouse) |
| ERK-1/2 (total) (mouse) | MCP-1 (rat) | TNF-RII |
| ERK-1/2 (total) (rat) | MCP-2 | TNF-RII (mouse) |
| ERK-5 (pT218/pY220) | MCP-3 | TNFα |
| E-Selectin | MCP-4 | TNFα (canine) |
| Estradiol | M-CSF | TNFα (mouse) |
| Estradiol (mouse) | M-CSF (mouse) | TNFα (rat) |
| Estradiol (rat) | MDC | Total Abeta |
| FABP3 (rat) | MDM2 - p53 complex | Total GLP-1 (canine) |
| FasL | MDM2 (self-ubiquitinated) | Total GLP-1 (ver. 2) |
| Ferritin | MDM2 (total) | Total GLP-1 (ver. 2) (mouse) |
| FGF (acidic) | MDM2 (ubiquitinated) | Total GLP-1 (ver. 2) (rat) |
| FGF (basic) | MDM2 (ubiquitinated) (mouse) | Total PAI-1 |
| Folate | MDM2 (ubiquitinated) (rat) | Total PAI-1 (mouse) |
| FOXO3a (pT32) | MEK1/2 (pS217/221) | Total PYY |
| FOXO3a (pT32) (mouse) | MEK1/2 (pS217/221) (mouse) | Total PYY (mouse) |
| FOXO3a (pT32) (rat) | MEK1/2 (pS217/221) (rat) | Total PYY (rat) |
| Free hCGß | MEK1/2 (total) | Total T3 |
| Free T3 | MEK1/2 (total) (mouse) | Total T4 |
| Free T4 | MEK1/2 (total) (rat) | tPA |
| FRS2 (pY196) | MEK2 (total) | TPOAb |
| FRS2 (pY436) | MEK2 (total) (rat) | Troponin I (cTnI) |
| FSH | MEK2 (total) (mouse) | Troponin ITC Complex (rat) |
| GAPDH | Met (pY1349) | Troponin T (cTnT) |
| G-CSF | Met (total) | TSH |
| Ghrelin (mouse) | MIG | TSLP |
| Ghrelin (rat) | MIP-1a | Tuberin (pT1462) |
| GLP-1 | MIP-1a (mouse) | TWEAK |
| GLP-1 (x-36) amide | MIP-1b | uE3 |
| GLP-1 (x-36) amide (mouse) | MIP-1b (mouse) | uPA |
| GLP-1 (x-36) amide (rat) | MIP-2 (mouse) | VASP (pS157) |
| Glucagon | MIP-3a | VASP (pS239) |
| Glucagon (mouse) | MIP-3a (mouse) | VASP (total) |
| Glucagon (rat) | MIP-3a (rat) | VEGF |
| GM-CSF | MIP-3ß | VEGF(121/165) |
| GM-CSF (canine) | MMP-1 | VEGF(121/165) (mouse) |
| GM-CSF (mouse) | MMP-10 | VEGF(121/165) (rat) |
| GM-CSF (rat) | MMP-2 | VEGFA (mouse) |
| GRO-a | MMP-3 | VEGFB |
| Growth Hormone (GH) | MMP-3 | VEGFC |
| GSK-3a (pS21) | MMP-8 | VEGF-C |
| GSK-3a (total) | MMP-9 | VEGFD |
| GSK-3b (pS9) | MMP-9 (mouse) | VEGF-D |
| GSK-3b (pS9) (mouse) | MMP9 (mouse) | VEGFR-2 (pY1054) |
| GSK-3b (pS9) (rat) | MPO | VEGFR-2 (pY1175) (mouse) |
| GSK-3b (total) | mTOR (pS2448) | VEGFR-2 (total) |
| GSK-3b (total) (mouse) | Myeloperoxidase | β-NGF |
